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Efficacy dilution in randomized placebo-controlled vaginal microbicide trials

Benoît R Mâsse1 email, Marie-Claude Boily2 email, Dobromir Dimitrov1 email and Kamal Desai2 email

Statistical Center for HIV/AIDS Research & Prevention, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

Department of Infectious Disease Epidemiology, Imperial College, UK

author email corresponding author email

Emerging Themes in Epidemiology 2009, 6:5doi:10.1186/1742-7622-6-5

Published: 9 October 2009

Additional files

Additional file 1:

Results of completed effectiveness trials of candidate vaginal microbicides for the prevention of HIV acquisition [1-3,16-20]. Table showing the results of completed effectiveness trials of candidate vaginal microbicides for the prevention of HIV acquisition.

Format: DOC Size: 81KB Download file

This file can be viewed with: Microsoft Word Viewer

Additional file 2:

Description and computational details of the different dilution factors, expected effectiveness and total dilution effect [9,21]. Table showing the description and computational details of the different dilution factors, expected effectiveness and total dilution effect.

Format: DOC Size: 49KB Download file

This file can be viewed with: Microsoft Word Viewer

Additional file 3:

Percent reduction (D) and expected effectiveness (Eall) for four scenarios of dilution with different true efficacy of active gel (ET). Table showing the percent reduction (D) and expected effectiveness (Eall) for four scenarios of dilution with different true efficacy of active gel (ET).

Format: DOC Size: 40KB Download file

This file can be viewed with: Microsoft Word Viewer


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