Table 1 |
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|
Statistical findings of data simulation using log-linear models (scenario outlined in Figure 5) |
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| Gene → asthma (βITT) |
Gene → gene expression of CC (βXG*) |
Gene expression of CC → asthma (βIV ') |
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|
|
||||||
| β |
SE |
 |
SE |
β |
SE |
|
|
|
||||||
| Effect of genetic polymorphism on asthma |
||||||
| CG/GG (reference) |
1 |
|||||
| CC |
0.458 |
0.141 |
||||
|
|
||||||
| Effect of genetic polymorphisms on gene expression: |
||||||
| CG/GG (reference) |
1 |
|||||
| CC |
0.367 |
0.055 |
||||
|
|
||||||
| Effect of genetic polymorphism, maternal and offspring smoking, and gene-"maternal smoking in adolescence" interaction on gene expression: |
||||||
| CG/GG (reference) |
1 |
|||||
| CC |
0.215 |
0.086 |
||||
| Maternal smoking |
0.983 |
0.086 |
||||
| "Maternal smoking in adolescence" × CC-genotype |
0.269 |
0.111 |
||||
| Offspring smoking |
-0.005 |
0.056 |
||||
|
|
||||||
| Effect of expression of genetic olymorphism on asthma: |
||||||
| Gene expression of CC |
1.951 |
0.135 |
||||
|
|
||||||
| Effect of genetic polymorphism, maternal and offspring smoking on asthma |
||||||
| Gene expression of CC |
1.792 |
0.144 |
||||
| "Maternal smoking in adolescence" |
0.435 |
0.145 |
||||
| Offspring smoking |
0.166 |
0.140 |
||||
|
# SE = standard error | ||||||
Ogbuanu et al. Emerging Themes in Epidemiology 2009 6:3 doi:10.1186/1742-7622-6-3 |
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