|
Randomised controlled trials of HIV prevention with HIV incidence as an outcome for sexual transmission |
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| Intervention |
Individual or cluster randomization |
RCTs completed or stopped |
RCTs showing efficacy |
RCTs ongoing |
|
|
||||
| Individual |
2 |
0 |
0 |
|
| [3,24] |
||||
| Behavior change (abstinence/delay, sex partner reduction, counseling and testing, condoms, diaphragms, microfinance) |
|
|||
| Cluster |
5 |
0 |
2 |
|
| [15,25-28] |
[29,30] |
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|
|
||||
| Male Circumcision |
Individual |
4 1 |
3 |
0 |
| [5-7,31] |
[5-7] |
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|
|
||||
| Microbicides |
Individual |
9 |
0 |
3 |
| [32-40] |
[41-43] |
|||
|
|
||||
| Oral pre-exposure prophylaxis (PrEP) |
Individual |
1 |
0 |
4 |
| [35] |
[44-47] |
|||
|
|
||||
| HIV Treatment |
Individual |
0 |
0 |
1 |
| [48] |
||||
|
|
||||
| Individual |
3 |
0 |
1 |
|
| [1,2,14] |
[49] |
|||
| STI Treatment |
|
|||
| Cluster |
4 |
1 |
0 |
|
| [8,15,16,50] |
[8] |
|||
|
|
||||
| HIV Vaccines |
Individual |
4 |
0 |
1 |
| [4,51-53] |
[54] |
|||
|
|
||||
| All Interventions |
312 |
4 |
12 |
|
|
1 The trial which did not show efficacy was of the impact of male circumcision on female HIV acquisition 2 Total = 31 trials because study [15] is shown twice, under behavior change and STI treatment | ||||
Weiss et al. Emerging Themes in Epidemiology 2008 5:8 doi:10.1186/1742-7622-5-8 |
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