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Meta-analyses Selected for Review |
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| Brief Title |
Year |
Medical Condition |
Treatment 1 v Treatment 2 |
Failure Outcome |
No. of studies (RCT, OS) |
Reasons for excluding OSs previously compared to RCTs [13] |
|
|
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| Anticoagulants |
1977 |
Myocardial Infarction |
Control v Anticoagulants |
Mortality |
Ioannidis: (6, 12) Kunz: (6, 12) |
Three used alternately assigned controls [23-25]. |
| Quinidine |
1992 |
Atrial fibrillation |
Control v Quinidine |
Relapse into atrial fibrillation |
Ioannidis: (6, 5) Kunz: (6, 6) |
One did not have 3-month follow-up [53]. |
| Trial of Labor |
1995 |
Breech delivery |
No trial v Trial of Labor |
5 minute Apgar |
Ioannidis: (2, 6) |
None excluded. |
| Colposuspension 1 |
1996 |
Incontinence |
Anterior colporrhaphy v Colposuspension |
No cure of incontinence |
Ioannidis: (4, 11) |
Five were in a foreign language [54-58]. |
| Colposuspension 2 |
1996 |
Incontinence |
Needle suspension v Colposuspension |
No cure of incontinence |
Ioannidis: (3, 9) |
One used failed surgery instead of incontinence as an outcome [59]. One was a controlled trial [26]. Three were in a foreign language [55, 56, 60]. |
| Transcutaneous Electrical Nerve Stimulation (TENS) |
1996 |
Post-operative pain |
Control v TENS |
No pain relief |
Ioannidis: (2, 4) Kunz: (17, 19) |
None excluded. |
| Early Discharge |
1997 |
Childbirth |
Conventional v Early |
Maternal Morbidity |
Ioannidis: (1, 3) |
Added one study from original meta-analysis [36]. |
| Hip screw |
1999 |
Hip fracture |
Fixed nail plates v Sliding hip screw |
Total complications |
Ioannidis: (1, 6) |
One "OS" was an RCT [27]. |
| Local Anesthesia |
1996 |
Carotid Endarterectomy |
General v Local Anesthesia |
Stroke or death |
Ioannidis: (3, 14) |
One from a non-peer reviewed abstract [61], 1 from unpublished data [62], one in a foreign language [63]. |
| Hysterosalpingo-graphy (HSG) |
1999 |
Infertility |
Water v Oil in Hysterosalpingography |
No Pregnancy |
Ioannidis: (5, 6) |
None excluded. |
|
RCT = Randomized Controlled Trial OS = Observational Study | ||||||
Hartz et al. Emerging Themes in Epidemiology 2005 2:8 doi:10.1186/1742-7622-2-8 |
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